Puros Dermis  Features & Benefits

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Zimmer Dental is pleased to announce the launch of the Puros® Dermis Allograft Tissue Matrix in the Americas – now available in two thicknesses

The Natural Choice for Soft Tissue Augmentation

Offering an easy-to-use, sterile solution, Puros Dermis is a natural alternative to autogenous soft tissue grafts. It can be used for both horizontal and vertical soft tissue augmentation, to increase volume and provide a highly cosmetic clinical result. Puros Dermis exhibits superb soft tissue response and maturation, ideal for aesthetic case requirements.

• A natural biological matrix designed for successful soft tissue enhancement, periodontal/peri-implant soft tissue management, and Guided Tissue Regeneration procedures
• Reduces morbidity and saves valuable chair time by eliminating the need for a secondary surgical procedure to harvest an autogenous graft
• Provides an excellent healing environment and acts as a guide for the regeneration of vital soft tissue¹
• Retains the natural collagen matrix and mechanical properties of native dermis due to the proprietary Tutoplast® Process²
• Excellent handling, rapid hydration, five-year shelf life and room temperature storage

A Variety of Clinical Advantages

Puros Dermis is a high-quality regenerative material, exhibiting multidirectional strength and exceptional adaptability to surface contours. Other membranes are freeze-dried, which can cause damage to the strength and integrity of the material³.

Puros Dermis Allograft Tissue Matrix is a high-quality regenerative material, exhibiting multidirectional strength and exceptional adaptability to surface contours Excellent handling characteristics – rehydrates in seconds, no refrigeration required, packaged sterile and no residual antibiotics Long history of effective clinical results in a variety of surgical applications4 Volume enhancement – maintains space for angiogenesis and tissue remodeling, and increases the volume of attached gingiva and connective tissue5 Wound stabilization – collagen helps stabilize and maintain blood clot in the defect space6 Puros Dermis has a resorption profile of 4 to 6 months. The timeframe for remodeling depends upon the following factors: Size of implant; vascularization of implant site; patient age, health and metabolic and nutritional status; biomechanical load on the graft Biocompatible and absorbable; easily assimilated into the body’s normal tissue healing process Four convenient sizes can be cut to shape for specific procedures

The Unique Tutoplast Process

The Puros Allograft family of products is refined using the proprietary, 5-stage Tutoplast sterilization process. While preserving the valuable collagen matrix and tissue integrity, this process gently removes unwanted materials such as cells, antigens and viruses, as well as inactivating pathogens. Tutoplast-Processed tissues have been used for over 30 years in more than one million procedures without a single reported case of disease transmission.

1. Osmotic treatment – Kills bacteria, destroys and removes unwanted cells, further reduces viral load
2. Oxidative treatment – Destroys remaining proteins and minimized potential graft rejection
3. Alkaline treatment – Further reduces prion infectivity
4. Solvent dehydration – Removes water from tissue and acts as a disinfectant, further reducing prions
5. Limited-dose gamma irradiation – Provides a sterility level of 10^-6 and preserves graft integrity

Is the Tutoplast process different for soft tissue and hard tissue?

There is one slight difference between the hard and soft tissue processing. Hard tissue processing utilizes a delipidization step to inactivate lipid-enveloped viruses (such as HIV and HCV) and to remove fat, enhancing the healing characteristics. Soft tissue (pericardium) processing mechanically removes fat and includes an alkaline treatment of 1N sodium hydroxide (NaOH), at room temperature, for one hour. This processing step is scientifically recognized as an acceptable and effective methodology for reducing prion infectivity. Tutoplast processing has been shown to reduce the viral load of tissues by 12 logs, which is 10,000 times higher than any viral load ever recorded in a human patient.

The Tutoplast® Process has been fully validated for preservation of tissue biomechanical properties, viral inactivation, prion inactivation, healing and elimination of antigenicity.

^1,2,3,4,5Data On File

Take a closer look

Figure A	Figure B	Figure C	Figure D
Preoperative clinical View.	Puros Dermis surgically placed.	10-day postoperative: note excellent soft tissue integration..	30-day postoperative: note esthetic tissue blending and color match .

Clinical photographs courtesy of Paul S. Petrungaro, DDS., M.S. Individual results may vary.

Tutoplast is a registered trademark of Tutogen Medical, Inc.